Two sample MR report

Telomere_length against IDP dMRI TBSS OD Cingulum cingulate gyrus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0591207	0.1616810	0.7182744
Weighted median	23	-0.0803460	0.0619941	0.1949661
Inverse variance weighted	23	-0.0266908	0.0618036	0.6658397
Simple mode	23	-0.2631818	0.1147459	0.0317347
Weighted mode	23	0.0072768	0.0714961	0.9198545

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	54.47338	21	0.0000843
Inverse variance weighted	54.59655	22	0.0001355

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0019913	0.0091383	0.8296031

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001668	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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