Two sample MR report

Telomere_length against IDP dMRI TBSS OD Cingulum cingulate gyrus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0764733	0.1553611	0.6276639
Weighted median	23	-0.0290931	0.0601617	0.6286827
Inverse variance weighted	23	-0.0420002	0.0594024	0.4795380
Simple mode	23	-0.0494527	0.1045879	0.6409891
Weighted mode	23	-0.0160329	0.0677294	0.8150641

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	50.29702	21	0.0003316
Inverse variance weighted	50.43620	22	0.0005119

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0021168	0.0087811	0.8118461

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015629	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8