Two sample MR report

Telomere_length against IDP dMRI TBSS OD Cerebral peduncle R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0590226	0.1508019	0.6994509
Weighted median	23	0.0129682	0.0559078	0.8165720
Inverse variance weighted	23	0.0124547	0.0579421	0.8298060
Simple mode	23	0.1156991	0.1089235	0.2996643
Weighted mode	23	-0.0009630	0.0642891	0.9881834

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	47.38782	21	0.0008326
Inverse variance weighted	47.98616	22	0.0010896

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.004389	0.0085234	0.6119775

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014571	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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