Two sample MR report

Telomere_length against IDP dMRI TBSS OD Cerebral peduncle L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0650298	0.1630812	0.6940976
Weighted median	23	-0.0255805	0.0598237	0.6689440
Inverse variance weighted	23	0.0198204	0.0627404	0.7520706
Simple mode	23	-0.0320476	0.1020894	0.7565412
Weighted mode	23	-0.0376560	0.0613684	0.5457683

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	55.42069	21	6.14e-05
Inverse variance weighted	56.26389	22	7.84e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0052101	0.0092174	0.5778949

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0017125	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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