Two sample MR report

Telomere_length against IDP dMRI TBSS MO Uncinate fasciculus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0424348	0.1180212	0.7227721
Weighted median	23	-0.0009256	0.0584827	0.9873729
Inverse variance weighted	23	-0.0446800	0.0457481	0.3287408
Simple mode	23	-0.0144288	0.1056187	0.8925797
Weighted mode	23	-0.0010451	0.0635874	0.9870346

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.02587	21	0.1133819
Inverse variance weighted	29.91468	22	0.1205530

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0053492	0.0066707	0.4315903

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009458	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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