Two sample MR report

Telomere_length against IDP dMRI TBSS MO Uncinate fasciculus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2885625	0.1400496	0.0519616
Weighted median	23	0.0288490	0.0595331	0.6279690
Inverse variance weighted	23	-0.0208531	0.0603653	0.7297571
Simple mode	23	-0.0691210	0.0994766	0.4944252
Weighted mode	23	0.0362994	0.0773132	0.6433244

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.87438	21	0.0058111
Inverse variance weighted	52.08764	22	0.0003040

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0189997	0.0079159	0.0257368

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015866	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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