Two sample MR report

Telomere_length against IDP dMRI TBSS MO Tapetum R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0024875	0.1359728	0.9855769
Weighted median	23	-0.0784857	0.0687755	0.2537924
Inverse variance weighted	23	-0.0322659	0.0520131	0.5350333
Simple mode	23	-0.1724506	0.1507589	0.2649664
Weighted mode	23	-0.1359860	0.1101512	0.2300264

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.52912	21	0.0111659
Inverse variance weighted	38.67058	22	0.0153886

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.002134	0.0076854	0.7839781

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011923	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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