Two sample MR report

Telomere_length against IDP dMRI TBSS MO Tapetum L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0642245	0.1148004	0.5817761
Weighted median	23	0.0478797	0.0616295	0.4372203
Inverse variance weighted	23	0.0123463	0.0440849	0.7794338
Simple mode	23	-0.0491505	0.1168352	0.6780684
Weighted mode	23	0.0571397	0.0697732	0.4216064

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.46422	21	0.1560106
Inverse variance weighted	27.77944	22	0.1831063

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0031856	0.0064887	0.6285568

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008448	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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