Two sample MR report

Telomere_length against IDP dMRI TBSS MO Sagittal stratum R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1626190	0.1131457	0.1653799
Weighted median	23	0.0746381	0.0557168	0.1803758
Inverse variance weighted	23	0.0538008	0.0443109	0.2246849
Simple mode	23	0.0315950	0.0903155	0.7297935
Weighted mode	23	0.0867019	0.0630525	0.1829509

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.6781	21	0.1817637
Inverse variance weighted	28.0650	22	0.1735371

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.006682	0.0063952	0.307971

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009074	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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