Two sample MR report

Telomere_length against IDP dMRI TBSS MO Sagittal stratum L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1226999	0.1192249	0.3151194
Weighted median	23	0.0559735	0.0596952	0.3484219
Inverse variance weighted	23	0.0513707	0.0459785	0.2638767
Simple mode	23	-0.1036711	0.1061270	0.3392593
Weighted mode	23	0.0704580	0.0703612	0.3275332

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.62155	21	0.0998609
Inverse variance weighted	30.21744	22	0.1132745

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.00438	0.0067388	0.5227621

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009676	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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