Two sample MR report

Telomere_length against IDP dMRI TBSS MO Pontine crossing tract

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1590540	0.1261089	0.2210530
Weighted median	23	0.1031597	0.0660847	0.1185188
Inverse variance weighted	23	0.0356122	0.0494313	0.4712550
Simple mode	23	0.2250079	0.1428836	0.1295832
Weighted mode	23	0.1735141	0.0921801	0.0730842

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.14172	21	0.0446691
Inverse variance weighted	34.92643	22	0.0394362

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.00758	0.0071279	0.2996659

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010833	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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