Two sample MR report

Telomere_length against IDP dMRI TBSS MO Middle cerebellar peduncle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1746929	0.1059594	0.1140947
Weighted median	23	0.1054722	0.0562496	0.0607824
Inverse variance weighted	23	0.0226522	0.0427351	0.5960687
Simple mode	23	0.1170240	0.0844285	0.1796145
Weighted mode	23	0.0997304	0.0584356	0.1019610

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.39671	21	0.3231966
Inverse variance weighted	26.10414	22	0.2472376

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.009336	0.005989	0.1339706

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008011	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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