Two sample MR report

Telomere_length against IDP dMRI TBSS MO Medial lemniscus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1119441	0.1343609	0.4141305
Weighted median	23	0.0233027	0.0593826	0.6947505
Inverse variance weighted	23	-0.0255346	0.0527898	0.6285964
Simple mode	23	0.0209065	0.1098248	0.8507711
Weighted mode	23	0.0209065	0.0637250	0.7459580

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.61956	21	0.0142761
Inverse variance weighted	39.83316	22	0.0113072

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0084418	0.0075942	0.2788713

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012198	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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