Two sample MR report

Telomere_length against IDP dMRI TBSS MO Medial lemniscus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1005499	0.1003867	0.3279268
Weighted median	23	-0.0087252	0.0578283	0.8800691
Inverse variance weighted	23	-0.0173381	0.0392322	0.6585358
Simple mode	23	-0.0466457	0.0970497	0.6355192
Weighted mode	23	-0.0138973	0.0704106	0.8453467

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.54779	21	0.6141238
Inverse variance weighted	20.17546	22	0.5720650

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0072389	0.005674	0.2159573

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006173	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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