Two sample MR report

Telomere_length against IDP dMRI TBSS MO Fornix

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0213697	0.1003863	0.8334779
Weighted median	23	-0.0824417	0.0536065	0.1240720
Inverse variance weighted	23	-0.0740145	0.0392322	0.0592174
Simple mode	23	-0.0039168	0.0945293	0.9673229
Weighted mode	23	-0.0778844	0.0600986	0.2084266

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.01505	21	0.8689519
Inverse variance weighted	15.08063	22	0.8587547

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.005857	0.005674	0.3136895

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005648	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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