Two sample MR report

Telomere_length against IDP dMRI TBSS MO External capsule R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1723142	0.1182365	0.1598070
Weighted median	23	-0.0617133	0.0557656	0.2684422
Inverse variance weighted	23	-0.0144446	0.0473533	0.7603369
Simple mode	23	-0.0639965	0.0847950	0.4584203
Weighted mode	23	-0.0725411	0.0562604	0.2106573

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.13169	21	0.1108756
Inverse variance weighted	32.05059	22	0.0765375

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0096939	0.0066829	0.1616752

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009753	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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