Two sample MR report

Telomere_length against IDP dMRI TBSS MO External capsule L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1836206	0.1279137	0.1658719
Weighted median	23	-0.0745976	0.0553376	0.1776437
Inverse variance weighted	23	-0.0300096	0.0507816	0.5545507
Simple mode	23	-0.0209895	0.1006393	0.8367095
Weighted mode	23	-0.0701950	0.0606057	0.2591921

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.09638	21	0.0353877
Inverse variance weighted	36.86001	22	0.0245061

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0094324	0.0072298	0.2061281

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011346	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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