Two sample MR report

Telomere_length against IDP dMRI TBSS MO Cingulum hippocampus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1068674	0.1233382	0.3960313
Weighted median	23	0.0490234	0.0602689	0.4159826
Inverse variance weighted	23	-0.0087553	0.0482423	0.8559858
Simple mode	23	-0.0818158	0.1183366	0.4965574
Weighted mode	23	0.0283302	0.0669781	0.6764179

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.70006	21	0.0627704
Inverse variance weighted	33.26577	22	0.0582319

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0070998	0.0069712	0.3200603

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010095	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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