Two sample MR report

Telomere_length against IDP dMRI TBSS MO Cingulum hippocampus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0955161	0.1003871	0.3521855
Weighted median	23	0.0263059	0.0561253	0.6392840
Inverse variance weighted	23	0.0141892	0.0392322	0.7175981
Simple mode	23	0.1615948	0.1065683	0.1436693
Weighted mode	23	-0.0411667	0.0708696	0.5672255

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.60563	21	0.6738062
Inverse variance weighted	19.01517	22	0.6443916

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0067364	0.005674	0.2483889

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005802	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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