Two sample MR report

Telomere_length against IDP dMRI TBSS MO Cingulum cingulate gyrus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0481633	0.1546220	0.7584990
Weighted median	23	0.0456502	0.0713166	0.5221039
Inverse variance weighted	23	0.0276029	0.0590675	0.6402773
Simple mode	23	0.0853101	0.1610641	0.6016488
Weighted mode	23	-0.1188446	0.0928680	0.2139768

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	49.82327	21	0.0003860
Inverse variance weighted	49.87278	22	0.0006101

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0012625	0.0087395	0.8865142

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015261	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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