Two sample MR report

Telomere_length against IDP dMRI TBSS MO Cingulum cingulate gyrus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0862861	0.1266271	0.5030523
Weighted median	23	0.0208504	0.0618843	0.7361733
Inverse variance weighted	23	0.0455434	0.0484897	0.3476087
Simple mode	23	0.1102696	0.1183368	0.3615390
Weighted mode	23	-0.0151868	0.0830990	0.8566632

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.41369	21	0.0418265
Inverse variance weighted	33.60811	22	0.0538167

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0025018	0.0071571	0.730155

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010592	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8