Two sample MR report

Telomere_length against IDP dMRI TBSS MO Cerebral peduncle R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1084466	0.1376621	0.4396310
Weighted median	23	-0.0061698	0.0598516	0.9178957
Inverse variance weighted	23	-0.0135770	0.0537109	0.8004390
Simple mode	23	-0.0196201	0.1083643	0.8579808
Weighted mode	23	-0.0096407	0.0742080	0.8978141

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.49152	21	0.0085692
Inverse variance weighted	41.23542	22	0.0077252

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0074928	0.0077808	0.3465141

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012531	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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