Two sample MR report

Telomere_length against IDP dMRI TBSS MO Cerebral peduncle L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0875924	0.1516596	0.5697029
Weighted median	23	-0.0054667	0.0597913	0.9271513
Inverse variance weighted	23	-0.0126862	0.0586149	0.8286500
Simple mode	23	0.0934411	0.1128268	0.4164617
Weighted mode	23	0.0221676	0.0712519	0.7586409

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	47.93105	21	0.0007027
Inverse variance weighted	49.10881	22	0.0007728

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0061575	0.0085719	0.4804654

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014911	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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