Two sample MR report

Telomere_length against IDP dMRI TBSS MD Uncinate fasciculus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2094143	0.1003841	0.0493489
Weighted median	23	0.2240179	0.0547233	0.0000425
Inverse variance weighted	23	0.2256208	0.0392311	0.0000000
Simple mode	23	0.2465360	0.0878031	0.0102516
Weighted mode	23	0.1933129	0.0611012	0.0044993

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.48110	21	0.8480607
Inverse variance weighted	14.51187	22	0.8823215

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0009952	0.0056739	0.8624509

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001442	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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