Two sample MR report

Telomere_length against IDP dMRI TBSS MD Uncinate fasciculus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0736716	0.1325514	0.5842233
Weighted median	23	0.1642125	0.0565578	0.0036908
Inverse variance weighted	23	0.2104781	0.0521041	0.0000535
Simple mode	23	0.2544156	0.0863410	0.0074604
Weighted mode	23	0.1321456	0.0595005	0.0369629

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.61490	21	0.0186301
Inverse variance weighted	38.80701	22	0.0148475

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0084006	0.007492	0.27483

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0020475	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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