Two sample MR report

Telomere_length against IDP dMRI TBSS MD Tapetum R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0204890	0.1003873	0.8402406
Weighted median	23	0.0745000	0.0563306	0.1859852
Inverse variance weighted	23	0.1057595	0.0392321	0.0070233
Simple mode	23	0.0413646	0.0932971	0.6618319
Weighted mode	23	0.0592540	0.0609944	0.3418768

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.08884	21	0.5156406
Inverse variance weighted	20.94040	22	0.5244239

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.005236	0.005674	0.3665913

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008547	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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