Two sample MR report

Telomere_length against IDP dMRI TBSS MD Tapetum L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0356961	0.1003875	0.7256999
Weighted median	23	0.0591446	0.0545319	0.2781044
Inverse variance weighted	23	0.1000288	0.0392322	0.0107827
Simple mode	23	0.0722431	0.0826315	0.3914099
Weighted mode	23	0.0589726	0.0562355	0.3057139

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.82836	21	0.5961495
Inverse variance weighted	19.31307	22	0.6259246

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0039503	0.0056741	0.4939305

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007822	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8