Two sample MR report

Telomere_length against IDP dMRI TBSS MD Sagittal stratum R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3601683	0.1501429	0.0258124
Weighted median	23	0.2291225	0.0599943	0.0001340
Inverse variance weighted	23	0.3206063	0.0574392	0.0000000
Simple mode	23	0.2755274	0.0933477	0.0073751
Weighted mode	23	0.2358380	0.0620368	0.0009773

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	46.98170	21	0.0009445
Inverse variance weighted	47.16503	22	0.0013966

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0024294	0.0084865	0.777483

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0034521	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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