Two sample MR report

Telomere_length against IDP dMRI TBSS MD Sagittal stratum L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1969777	0.1873942	0.3051402
Weighted median	23	0.1965872	0.0607155	0.0012044
Inverse variance weighted	23	0.2756055	0.0719031	0.0001266
Simple mode	23	0.1470578	0.0957542	0.1388491
Weighted mode	23	0.1720610	0.0609136	0.0098662

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	73.18393	21	1e-07
Inverse variance weighted	73.90805	22	2e-07

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0048281	0.0105918	0.6531873

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0037338	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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