Two sample MR report

Telomere_length against IDP dMRI TBSS MD Pontine crossing tract

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0566483	0.1036572	0.5904851
Weighted median	23	0.0197284	0.0618347	0.7496882
Inverse variance weighted	23	0.0083796	0.0400142	0.8341230
Simple mode	23	0.0537852	0.1056227	0.6156678
Weighted mode	23	0.0447826	0.0809048	0.5854880

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.39085	21	0.3772948
Inverse variance weighted	22.88611	22	0.4081845

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0039931	0.0058589	0.502979

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006949	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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