Two sample MR report

Telomere_length against IDP dMRI TBSS MD Middle cerebellar peduncle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3494735	0.1200536	0.0083543
Weighted median	23	0.0903943	0.0640976	0.1584628
Inverse variance weighted	23	0.1403942	0.0495937	0.0046419
Simple mode	23	-0.0086849	0.1116572	0.9387050
Weighted mode	23	0.0602541	0.0937002	0.5268366

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.03788	21	0.0912294
Inverse variance weighted	35.15829	22	0.0372945

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0128389	0.0067858	0.0723577

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014532	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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