Two sample MR report

Telomere_length against IDP dMRI TBSS MD Medial lemniscus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1471730	0.1104435	0.1969548
Weighted median	23	-0.0025584	0.0577857	0.9646855
Inverse variance weighted	23	0.0057685	0.0440702	0.8958587
Simple mode	23	-0.1042267	0.1051267	0.3322513
Weighted mode	23	0.0969509	0.0742845	0.2053350

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.41887	21	0.2294786
Inverse variance weighted	27.76074	22	0.1837465

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0086829	0.0062424	0.1788027

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008418	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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