Two sample MR report

Telomere_length against IDP dMRI TBSS MD Medial lemniscus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0864492	0.1171431	0.4686941
Weighted median	23	-0.0018172	0.0595001	0.9756357
Inverse variance weighted	23	0.0124837	0.0452267	0.7825296
Simple mode	23	0.0093896	0.1047569	0.9293904
Weighted mode	23	0.0128657	0.0773438	0.8694049

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.59626	21	0.1240367
Inverse variance weighted	29.23702	22	0.1382173

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0045418	0.0066211	0.5002381

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008889	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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