Two sample MR report

Telomere_length against IDP dMRI TBSS MD Fornix

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0398325	0.1177647	0.7385419
Weighted median	23	0.0015251	0.0601842	0.9797833
Inverse variance weighted	23	-0.0052084	0.0450752	0.9080103
Simple mode	23	0.0498319	0.1044649	0.6380522
Weighted mode	23	0.0145068	0.0748495	0.8481012

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.90108	21	0.1163968
Inverse variance weighted	29.04149	22	0.1436801

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0021261	0.0066562	0.7525679

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008806	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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