Two sample MR report

Telomere_length against IDP dMRI TBSS MD External capsule R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1761633	0.1428680	0.2311826
Weighted median	23	0.1401120	0.0592221	0.0179876
Inverse variance weighted	23	0.1594456	0.0545710	0.0034802
Simple mode	23	0.2269504	0.0980982	0.0304265
Weighted mode	23	0.1414974	0.0655208	0.0419721

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	42.53512	21	0.0036018
Inverse variance weighted	42.56786	22	0.0053317

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0010266	0.0080752	0.9000508

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0017899	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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