Two sample MR report

Telomere_length against IDP dMRI TBSS MD External capsule L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1218448	0.1457684	0.4126328
Weighted median	23	0.0895674	0.0552084	0.1047285
Inverse variance weighted	23	0.1381885	0.0556769	0.0130658
Simple mode	23	0.0818196	0.0870749	0.3576022
Weighted mode	23	0.0698772	0.0600346	0.2569132

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	44.27873	21	0.0021514
Inverse variance weighted	44.31002	22	0.0032432

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0010036	0.008239	0.9042096

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0017182	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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