Two sample MR report

Telomere_length against IDP dMRI TBSS MD Cingulum hippocampus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3683217	0.1041443	0.0019557
Weighted median	23	0.2741854	0.0617334	0.0000089
Inverse variance weighted	23	0.2516741	0.0411432	0.0000000
Simple mode	23	0.3768890	0.1132714	0.0030573
Weighted mode	23	0.3255561	0.0802391	0.0005245

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.60452	21	0.3654212
Inverse variance weighted	24.19834	22	0.3369194

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.007163	0.0058866	0.2371669

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0019802	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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