Two sample MR report

Telomere_length against IDP dMRI TBSS MD Cingulum hippocampus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2482300	0.1191836	0.0496853
Weighted median	23	0.1764569	0.0573363	0.0020869
Inverse variance weighted	23	0.1780030	0.0459491	0.0001071
Simple mode	23	0.0524144	0.1188648	0.6635464
Weighted mode	23	0.1871595	0.0657097	0.0093492

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.60302	21	0.1002603
Inverse variance weighted	30.18068	22	0.1141386

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0043124	0.0067365	0.5290023

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015381	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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