Two sample MR report

Telomere_length against IDP dMRI TBSS MD Cingulum cingulate gyrus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2666044	0.1401117	0.0708676
Weighted median	23	0.1946599	0.0572759	0.0006772
Inverse variance weighted	23	0.2185588	0.0536739	0.0000466
Simple mode	23	0.2108743	0.0937040	0.0347521
Weighted mode	23	0.1725613	0.0630560	0.0120442

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.91057	21	0.0057516
Inverse variance weighted	41.18094	22	0.0078419

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0029503	0.0079194	0.7132273

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0021879	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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