Two sample MR report

Telomere_length against IDP dMRI TBSS MD Cingulum cingulate gyrus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1907004	0.1458067	0.2050446
Weighted median	23	0.2075269	0.0588147	0.0004179
Inverse variance weighted	23	0.2705492	0.0561388	0.0000014
Simple mode	23	0.3043244	0.0998911	0.0059187
Weighted mode	23	0.1743722	0.0583455	0.0067708

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	44.30437	21	0.0021350
Inverse variance weighted	45.05114	22	0.0026145

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0049031	0.0082413	0.558235

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0028057	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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