Two sample MR report

Telomere_length against IDP dMRI TBSS MD Cerebral peduncle R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2671675	0.1517919	0.0929521
Weighted median	23	0.1279529	0.0586908	0.0292488
Inverse variance weighted	23	0.1549731	0.0588408	0.0084443
Simple mode	23	0.0594302	0.0969781	0.5462777
Weighted mode	23	0.1325988	0.0579917	0.0322133

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	48.01591	21	0.0006842
Inverse variance weighted	49.49023	22	0.0006870

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0068893	0.0085795	0.4309732

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0019723	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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