Two sample MR report

Telomere_length against IDP dMRI TBSS MD Cerebral peduncle L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0960576	0.1279731	0.4612171
Weighted median	23	0.0869099	0.0553469	0.1163510
Inverse variance weighted	23	0.1487876	0.0490958	0.0024411
Simple mode	23	0.0836942	0.0826047	0.3219838
Weighted mode	23	0.0836942	0.0588751	0.1691772

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.12832	21	0.0351094
Inverse variance weighted	34.45397	22	0.0441417

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0032379	0.0072332	0.6589968

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014797	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8