Two sample MR report

Telomere_length against IDP dMRI TBSS L3 Uncinate fasciculus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2622772	0.1055892	0.0215110
Weighted median	23	0.1365934	0.0591082	0.0208382
Inverse variance weighted	23	0.1607714	0.0413502	0.0001011
Simple mode	23	0.1402931	0.0940251	0.1498800
Weighted mode	23	0.1340702	0.0699986	0.0685400

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.23377	21	0.3316420
Inverse variance weighted	24.44053	22	0.3245685

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.006233	0.0059681	0.3081808

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012494	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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