Two sample MR report

Telomere_length against IDP dMRI TBSS L3 Uncinate fasciculus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1216930	0.1327394	0.3696665
Weighted median	23	0.1536691	0.0571357	0.0071549
Inverse variance weighted	23	0.1489542	0.0507428	0.0033304
Simple mode	23	0.1581125	0.0965607	0.1157638
Weighted mode	23	0.1675269	0.0716859	0.0289481

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.71833	21	0.0181312
Inverse variance weighted	36.80538	22	0.0248454

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.001674	0.0075027	0.8255996

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015517	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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