Two sample MR report

Telomere_length against IDP dMRI TBSS L3 Tapetum R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0597595	0.1079097	0.5855705
Weighted median	23	0.0613911	0.0586608	0.2953097
Inverse variance weighted	23	0.1109636	0.0414621	0.0074448
Simple mode	23	0.0490490	0.0891543	0.5877534
Weighted mode	23	0.0629108	0.0624550	0.3247431

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.26516	21	0.2803891
Inverse variance weighted	24.57222	22	0.3179654

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0031442	0.0060992	0.611584

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009869	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8