Two sample MR report

Telomere_length against IDP dMRI TBSS L3 Tapetum L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0645055	0.1102818	0.5648373
Weighted median	23	0.0662147	0.0561084	0.2379521
Inverse variance weighted	23	0.1000926	0.0422311	0.0177824
Simple mode	23	0.0892240	0.0823404	0.2902756
Weighted mode	23	0.0789538	0.0564070	0.1755424

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.34367	21	0.2325865
Inverse variance weighted	25.49199	22	0.2741307

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0021852	0.0062333	0.7294011

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009696	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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