Two sample MR report

Telomere_length against IDP dMRI TBSS L3 Sagittal stratum R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3643361	0.1488570	0.0232610
Weighted median	23	0.2277699	0.0616022	0.0002178
Inverse variance weighted	23	0.2992546	0.0571412	0.0000002
Simple mode	23	0.2232825	0.0926336	0.0247370
Weighted mode	23	0.2323062	0.0611790	0.0009879

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	46.18037	21	0.0012091
Inverse variance weighted	46.67649	22	0.0016170

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0039964	0.0084138	0.6397025

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0031768	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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