Two sample MR report

Telomere_length against IDP dMRI TBSS L3 Sagittal stratum L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2164080	0.1753725	0.2308387
Weighted median	23	0.1434573	0.0593690	0.0156763
Inverse variance weighted	23	0.2469915	0.0670171	0.0002283
Simple mode	23	0.1200084	0.0951197	0.2202859
Weighted mode	23	0.1590910	0.0635797	0.0202682

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	64.09400	21	3.0e-06
Inverse variance weighted	64.20356	22	5.2e-06

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.001878	0.0099124	0.8515532

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0031455	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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