Two sample MR report

Telomere_length against IDP dMRI TBSS L3 Pontine crossing tract

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0359467	0.1035253	0.7318773
Weighted median	23	0.0656151	0.0589871	0.2659816
Inverse variance weighted	23	0.0244228	0.0395424	0.5368158
Simple mode	23	0.0928989	0.1126683	0.4184863
Weighted mode	23	0.0869597	0.0772665	0.2725262

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.33391	21	0.3804918
Inverse variance weighted	22.34947	22	0.4392028

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0007076	0.0058514	0.9048944

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000689	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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