Two sample MR report

Telomere_length against IDP dMRI TBSS L3 Middle cerebellar peduncle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3530972	0.1214343	0.0084162
Weighted median	23	0.1397931	0.0610464	0.0220243
Inverse variance weighted	23	0.1674873	0.0493175	0.0006835
Simple mode	23	0.1474497	0.1096922	0.1925778
Weighted mode	23	0.1514854	0.0907842	0.1093615

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.73240	21	0.0782282
Inverse variance weighted	34.76773	22	0.0409645

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0113976	0.0068638	0.111664

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016056	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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